Fatty Acid Profile as an Indicator of Larval Host for Adult Drosophila suzukii

Drosophila suzukii a severe economic invasive pests of fruit crops were soft-skinned. Management usually requires killing the adult gravid female flies with insecticide to prevent damage caused by oviposition and larval development. The fruit of the host plant is cultivated and uncultivated used by the flies to reproduce at different times of the year, and the knowledge of the use of the host plant seasonal D. suzukii and movement patterns could be better utilized to protect vulnerable plants.

Maintenance and various methodologies mark for D. suzukii to track movement patterns in the different landscapes have been used to better understand the use of the host and the movement of pests. In this study, we report the potential to determine larval host adult D. suzukii using fatty acid profiles or signatures, and using larval diet as an internal marker of adult flies in the release-recapture experiments.

The fatty acids can pass efficiently through trophic level is modified, and the insects are limited in the ability to synthesize fatty acids and may get them through diet. In many insects holometabolous, lipid obtained in carry-larval stage to the adult stage. We tested the ability of machines to adult discrimination algorithm D. suzukii maintained on susceptible plant small fruits (blueberries, strawberries, blackberries and raspberries) and laboratory diets based on fatty acid profile of adult flies learn. We found that the fatty acid component in adult flies were significantly different when it flies reared on different hosts, and machine learning algorithms are very successful with properly classify their larval flies by host based fatty acid profile.


Chili plants Discaria chacaye, Talguenea quinquenervia (rhamnaceae), Peumus boldus (monimiaceae), and Cryptocarya alba (Lauraceae) was evaluated against Codling moth: Cydia pomonella L. (Lepidoptera: Tortricidae) and the fruit fly Drosophila melanogaster (Diptera: Drosophilidae), which is one of the major pests of the most extensive and damaging Prunus (plum, cherry, peach, nectarine, apricot, almond), pears, walnuts and chestnuts, among others. alkaloid four benzylisoquinoline (coclaurine, laurolitsine, Boldin, and pukateine) was isolated from the above mentioned plant species and evaluated for their insecticidal activity against Codling moths and fruit flies.

minor spliceosome disability-related SMA phenotype induced by intron-containing genes in Drosophila sensitive nerve

The minor spliceosome evolutionarily conserved in higher eukaryotes, but the remains poorly understood biological significance. Here disorders, by appropriate CRISPR / Cas9-mediated from U12 and U6atac snRNAs, we reported that the minor spliceosome defect responsible for spinal muscular atrophy (SMA) related phenotypes in Drosophila. Using the approach of bioinformatics newly developed, we identified a large set of minor spliceosome-sensitive events splicing and showed that the three sensitive genes nerve intron-containing, Pcyt2, Zmynd10, and Fas3, directly contributed to the development of the disease as evidenced by the ability of cDNA them to rescue the phenotype of SMA involved in the development of muscle, the neuromuscular junction, and motion.

Interestingly, many in the intron splice sites sensitive recognized by both minor and major spliceosome, suggesting a new mechanism of regulation of splicing through competition between mild and major spliceosome. These findings reveal the important contribution of small to high school spliceosome and splicing set in animals.The results showed that this alkaloid has the effect of acute and chronic insecticide. The most relevant effects were observed at 10 ug / mL against D. melanogaster and at 50 ug / mL against C. pomonella, be a change from eating, deformation, failure to transfer media feeding larvae in D. melanogaster, and the visible effects of death.

 Fatty Acid Profile as an Indicator of Larval Host for Adult Drosophila suzukii
Fatty Acid Profile as an Indicator of Larval Host for Adult Drosophila suzukii

The Bric-à-Brac BTB / POZ transcription factors required in the niche cells for the formation of germline stem cells and homeostasis through control of BMP / DPP signaling in Drosophila melanogaster ovary

Much research has focused on the mechanisms of stem cell maintenance through their interaction with specific niche or micro in adult tissues, but how the formation of a functional niche starts, including how stem cells in defined niche, is less well understood. Adult Drosophila melanogaster ovarian germline stem cell (GSC) niche consisting of somatic cells form a stack called Terminal Filament (TF) and related Cap and Escort Cell (CC and ECs, respectively), which are in direct contact with the GSCs. In the adult ovary, Engrailed transcription factor specifically expressed in a cell niche in which directly controls the expression decapentaplegic (dpp) gene that encodes a member of the Bone Morphogenetic Protein (BMP) family of secreted signaling molecule, which is a key factor for GSC maintenance. In the larval ovary, in response to BMP signal of recesses are formed, adjacent primordial germ cells into GSCs.

The bric-à-brac paralogs (CHAPTER 1 and Chapter 2) encode BTB / POZ domain-containing transcription factor expressed in the larval ovary develops niche. We show here that they required special functions in the cell precursors to the formation of TF during this stage. We also identified a new function for Chapter 1 and Chapter 2 in developing a niche for the establishment of GSC in larval ovary and to the maintenance of a strong GSC in adults.

Aspartate aminotransferase, cytoplasmic

AP79966 1mg
EUR 2640

Aspartate aminotransferase, cytoplasmic

AP80066 1mg
EUR 2640

Aspartate aminotransferase, cytoplasmic

AP80075 1mg
EUR 2640

Aspartate aminotransferase, cytoplasmic

AP80089 1mg
EUR 2640

Aspartate aminotransferase, cytoplasmic

AP80126 1mg
EUR 2640

Aspartate aminotransferase, cytoplasmic

AP80210 1mg
EUR 2640

Aspartate Aminotransferase Rabbit mAb

A11363-100ul 100 ul
EUR 492

Aspartate Aminotransferase Rabbit mAb

A11363-200ul 200 ul
EUR 685.2

Aspartate Aminotransferase Rabbit mAb

A11363-20ul 20 ul
EUR 265.2

Aspartate Aminotransferase Rabbit mAb

A11363-50ul 50 ul
EUR 344.4

Aspartate Aminotransferase Rabbit pAb

E2382123 100ul
EUR 225
Description: Available in various conjugation types.

Aspartate Aminotransferase Rabbit mAb

E2R23542 100ul
EUR 255
Description: Available in various conjugation types.

Aspartate Aminotransferase Rabbit mAb

E2R24263 100ul
EUR 255
Description: Available in various conjugation types.

Active Aspartate Aminotransferase (AST)

APB214Hu01 10ug
EUR 310

Active Aspartate Aminotransferase (AST)

APB214Mu01 10ug
EUR 240

Aspartate Aminotransferase Rabbit mAb

56284 100ul
EUR 339

Active Aspartate Aminotransferase (AST)

RPU59170-100ug 100ug
EUR 1064.8

Active Aspartate Aminotransferase (AST)

RPU59170-1mg 1mg
EUR 4422.6

Active Aspartate Aminotransferase (AST)

RPU59170-50ug 50ug
EUR 706.9

Aspartate aminotransferase, mitochondrial

AP80035 1mg
EUR 2640

Aspartate aminotransferase, mitochondrial

AP80049 1mg
EUR 2640

Aspartate aminotransferase, mitochondrial

AP80090 1mg
EUR 2640

Aspartate aminotransferase, mitochondrial

AP80112 1mg
EUR 2640

Aspartate aminotransferase, mitochondrial

AP80117 1mg
EUR 2640

Aspartate aminotransferase, mitochondrial

AP80150 1mg
EUR 2640

Aspartate Aminotransferase (AST) Antibody

20-abx102510
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Aspartate Aminotransferase (AST) Antibody

20-abx102511
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Aspartate Aminotransferase (AST) Antibody

20-abx102512
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Aspartate Aminotransferase (AST) Antibody

20-abx104813
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Aspartate Aminotransferase (AST) Antibody

20-abx131756
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Aspartate Aminotransferase (AST) Antibody

20-abx132273
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Aspartate Aminotransferase (AST) Antibody

20-abx175479
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Aspartate Aminotransferase (AST) Antibody

20-abx175481
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Aspartate Aminotransferase (AST) Antibody

20-abx171335
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Aspartate Aminotransferase (AST) Antibody

20-abx171336
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  • 1 mg
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Aspartate Aminotransferase (AST) Antibody

20-abx171337
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  • 1 mg
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Aspartate Aminotransferase Antibody (HRP)

GWB-10CABC 1 mg Ask for price

Native Human Aspartate Aminotransferase

NATE-0950 100 u
EUR 453.6

Native Human Aspartate Aminotransferase

NATE-0951 100 u
EUR 453.6

Aspartate Aminotransferase (GOT1) Antibody

20-abx109557
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Aspartate Aminotransferase (GOT1) Antibody

20-abx241031
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  • 100 ul
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Rat Aspartate Aminotransferase ELISA kit

E02A0626-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Aspartate Aminotransferase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Aspartate Aminotransferase ELISA kit

E02A0626-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Aspartate Aminotransferase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Aspartate Aminotransferase ELISA kit

E02A0626-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Aspartate Aminotransferase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Aspartate Aminotransferase ELISA kit

E01A9022 96T
EUR 700
Description: ELISA

Dog Aspartate Aminotransferase ELISA kit

E08A0626-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Aspartate Aminotransferase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Aspartate Aminotransferase ELISA kit

E08A0626-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Aspartate Aminotransferase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Aspartate Aminotransferase ELISA kit

E08A0626-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Aspartate Aminotransferase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Aspartate Aminotransferase ELISA kit

E07A0626-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Aspartate Aminotransferase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Aspartate Aminotransferase ELISA kit

E07A0626-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Aspartate Aminotransferase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Aspartate Aminotransferase ELISA kit

E07A0626-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Aspartate Aminotransferase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Aspartate Aminotransferase (AST) ELISA

KT-7818 96 tests
EUR 1032

Rat Aspartate Aminotransferase ELISA Kit

IRTASTKT each
EUR 754
Description: Rat Aspartate Aminotransferase ELISA Kit

Eukaryotic Aspartate Aminotransferase (AST)

EPB214Hu51 10ug
EUR 204

Eukaryotic Aspartate Aminotransferase (AST)

4-EPB214Hu51
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  • 100 ug
  • 10ug
  • 1 mg
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  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Aspartate Aminotransferase expressed in: Yeast

Eukaryotic Aspartate Aminotransferase (AST)

RPU54664-100ug 100ug
EUR 628.1

Eukaryotic Aspartate Aminotransferase (AST)

RPU54664-1mg 1mg
EUR 2784.6

Eukaryotic Aspartate Aminotransferase (AST)

RPU54664-50ug 50ug
EUR 504.9

Goat Aspartate Aminotransferase ELISA kit

E01A43943 96T
EUR 700
Description: ELISA

Goat Aspartate Aminotransferase ELISA kit

E06A0626-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Aspartate Aminotransferase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Aspartate Aminotransferase ELISA kit

E06A0626-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Aspartate Aminotransferase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Aspartate Aminotransferase ELISA kit

E06A0626-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Aspartate Aminotransferase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Recombinant Aspartate Aminotransferase (AST)

RPU56908-100ug 100ug
EUR 470.4

Recombinant Aspartate Aminotransferase (AST)

RPU56908-1mg 1mg
EUR 2184

Recombinant Aspartate Aminotransferase (AST)

RPU56908-50ug 50ug
EUR 385

Recombinant Aspartate Aminotransferase (AST)

RPU54347-100ug 100ug
EUR 591.8

Recombinant Aspartate Aminotransferase (AST)

RPU54347-1mg 1mg
EUR 2620.8

Recombinant Aspartate Aminotransferase (AST)

RPU54347-50ug 50ug
EUR 475.2

Recombinant Aspartate Aminotransferase (AST)

RPU40393-100ug 100ug
EUR 517

Recombinant Aspartate Aminotransferase (AST)

RPU40393-1mg 1mg
EUR 2293.2

Recombinant Aspartate Aminotransferase (AST)

RPU40393-50ug 50ug
EUR 415.8

Recombinant Aspartate Aminotransferase (AST)

RPU40394-100ug 100ug
EUR 591.8

Recombinant Aspartate Aminotransferase (AST)

RPU40394-1mg 1mg
EUR 2620.8

Recombinant Aspartate Aminotransferase (AST)

RPU40394-50ug 50ug
EUR 475.2

Recombinant Aspartate Aminotransferase (AST)

RPU40395-100ug 100ug
EUR 591.8

Recombinant Aspartate Aminotransferase (AST)

RPU40395-1mg 1mg
EUR 2620.8

Recombinant Aspartate Aminotransferase (AST)

RPU40395-50ug 50ug
EUR 475.2

Recombinant Aspartate Aminotransferase (AST)

RPB214Bo01 10ug
EUR 192

Recombinant Aspartate Aminotransferase (AST)

4-RPB214Bo01
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  • 100 ug
  • 10ug
  • 1 mg
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  • 5 mg
Description: Recombinant Bovine Aspartate Aminotransferase expressed in: E.coli

Recombinant Aspartate Aminotransferase (AST)

RPB214Hu01 10ug
EUR 168

Recombinant Aspartate Aminotransferase (AST)

4-RPB214Hu01
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  • 100 ug
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  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Aspartate Aminotransferase expressed in: E.coli

Recombinant Aspartate Aminotransferase (AST)

RPB214Mu01 10ug
EUR 192

Recombinant Aspartate Aminotransferase (AST)

4-RPB214Mu01
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Aspartate Aminotransferase expressed in: E.coli

Recombinant Aspartate Aminotransferase (AST)

RPB214Ra01 10ug
EUR 192

Recombinant Aspartate Aminotransferase (AST)

4-RPB214Ra01
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Aspartate Aminotransferase expressed in: E.coli

Rat Aspartate Aminotransferase (AST) Protein

20-abx065468
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  • 100 ug
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Cow Aspartate Aminotransferase (AST) Protein

20-abx166299
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  • 100 ug
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  • 1 mg
  • 200 ug
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Mouse Aspartate Aminotransferase ELISA kit

E01A17764 96T
EUR 700
Description: ELISA

Mouse Aspartate Aminotransferase ELISA kit

E03A0626-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Aspartate Aminotransferase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Aspartate Aminotransferase ELISA kit

E03A0626-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Aspartate Aminotransferase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Aspartate Aminotransferase ELISA kit

E03A0626-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Aspartate Aminotransferase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Sheep Aspartate Aminotransferase ELISA kit

E01A96236 96T
EUR 700
Description: ELISA

Human Aspartate Aminotransferase ELISA kit

E01A0626-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Aspartate Aminotransferase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Aspartate Aminotransferase ELISA kit

E01A0626-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Aspartate Aminotransferase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Aspartate Aminotransferase ELISA kit

E01A0626-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Aspartate Aminotransferase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Aspartate Aminotransferase ELISA kit

E01A0259 96T
EUR 700
Description: ELISA

Human Aspartate Aminotransferase (AST) ELISA

KT-33851 96 tests
EUR 931

Mouse Aspartate Aminotransferase ELISA Kit

IMSASTKT each
EUR 718
Description: Mouse Aspartate Aminotransferase ELISA Kit

Aspartate Aminotransferase 2 (GOT2) Antibody

20-abx110480
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  • 100 ug
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Aspartate Aminotransferase 1 (GOT1) Antibody

20-abx112757
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  • 150 ul
  • 50 ul

Aspartate Aminotransferase 2 (GOT2) Antibody

20-abx112758
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  • 150 ul
  • 50 ul

Aspartate Aminotransferase 2 (AST2) Antibody

20-abx102803
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  • 100 ug
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Aspartate Aminotransferase 2 (AST2) Antibody

20-abx102804
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  • 100 ug
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Aspartate Aminotransferase 2 (GOT2) Antibody

20-abx126923
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  • 100 ul
  • 200 ul

Aspartate Aminotransferase 2 (GOT2) Antibody

20-abx141922
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  • 100 ul
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Aspartate Aminotransferase 1 (GOT1) Antibody

20-abx137188
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  • 0.5 mg
  • 100 ug
  • 1 mg

Aspartate Aminotransferase 2 (GOT2) Antibody

20-abx007168
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  • 100 ul
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Aspartate Aminotransferase 1 (GOT1) Antibody

abx031813-400ul 400 ul
EUR 627.6

Aspartate Aminotransferase 1 (GOT1) Antibody

abx031813-80l 80 µl
EUR 343.2

Aspartate Aminotransferase 1 (GOT1) Antibody

abx031814-400ul 400 ul
EUR 627.6

Aspartate Aminotransferase 1 (GOT1) Antibody

abx031814-80l 80 µl
EUR 343.2

Aspartate Aminotransferase 2 (GOT2) Antibody

abx034181-400ul 400 ul
EUR 627.6

Aspartate Aminotransferase 2 (GOT2) Antibody

abx034181-80l 80 µl
EUR 343.2

Aspartate Aminotransferase 2 (GOT2) Antibody

abx018086-100ug 100 ug
EUR 460.8

Aspartate Aminotransferase 2 (GOT2) Antibody

20-abx018329
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  • 100 ug
  • 1 mg
  • 500 ug

Aspartate Aminotransferase 1 (GOT1) Antibody

20-abx004462
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  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Aspartate Aminotransferase 2 (GOT2) Antibody

abx010852-100ul 100 ul
EUR 493.2

Aspartate Aminotransferase 1 (GOT1) Antibody

20-abx009212
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  • 100 ul
  • 200 ul
  • 30 ul

Aspartate Aminotransferase 1 (GOT1) Antibody

abx233567-100ug 100 ug
EUR 577.2

Aspartate Aminotransferase 1 (GOT1) Antibody

abx233568-100ug 100 ug
EUR 661.2

Aspartate Aminotransferase 2 (GOT2) Antibody

abx233569-100ug 100 ug
EUR 577.2

Aspartate Aminotransferase (AST) Antibody (APC)

20-abx175480
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  • 1 mg
  • 200 ug

Aspartate Aminotransferase 2 (AST2) Antibody

20-abx175482
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  • 1 mg
  • 200 ug

Aspartate Aminotransferase 1 (GOT1) Antibody

abx431814-200ul 200 ul
EUR 460.8

Aspartate Aminotransferase 2 (GOT2) Antibody

abx432762-200ul 200 ul
EUR 460.8

Aspartate Aminotransferase 1 (GOT1) Antibody

abx431297-200ul 200 ul
EUR 460.8

Aspartate Aminotransferase 2 (GOT2) Antibody

abx431298-200ul 200 ul
EUR 460.8

Aspartate Aminotransferase 2 (GOT2) Antibody

abx431299-200ul 200 ul
EUR 460.8

Aspartate Aminotransferase 2 (GOT2) Antibody

20-abx241804
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  • 100 ul
  • 50 ul

Aspartate Aminotransferase 2 (GOT2) Antibody

abx340085-100ug 100 ug
EUR 469.2

Aspartate Aminotransferase 1 (GOT1) Antibody

abx340086-100ug 100 ug
EUR 469.2

Canine Aspartate Aminotransferase ELISA kit

E01A61378 96T
EUR 700
Description: ELISA

Monkey Aspartate Aminotransferase ELISA kit

E01A70090 96T
EUR 700
Description: ELISA

Rabbit Aspartate Aminotransferase ELISA kit

E01A26511 96T
EUR 700
Description: ELISA

Rabbit Aspartate Aminotransferase ELISA kit

E04A0626-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Aspartate Aminotransferase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Aspartate Aminotransferase ELISA kit

E04A0626-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Aspartate Aminotransferase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

In addition, we show that the presence of protein in the cell niche chapter is required for activation of the transgene report dpp expression in the larval stage in an otherwise correctly specified cells Cap, independently of its paralog Engrailed and Invected (En / Inv). In addition, a strong reduction engrailed / expression invected during the larval stage is not the formation of TF is harmless and only partially reduce the number of GSC.

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